3D COVID-19 Tissue Organoids to Severe AcuteRespiratory Syndrome (SARS-CoV), Urbani Strain.

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3D COVI-19 Tissue Organoids to Severe AcuteRespiratory Syndrome (SARS-CoV), Urbani Strain.

Negative Control Organoid. Day 10 i.c. Haematoxylin -Eosin (H&E)                                X 400.
Negative Control probed with SARS – CoV polyclonal spike antibody. Mayer’s Counterstain.Day 4 i.c. X 400.
Tissue organoid exposed to SAR-CoV. Hematoxylin-Eosin (H&E). Day 10 p.i.                      
SARS-CoV specific polyclonal nucleocapsid protein Ab. Day 4 p.i. Cell membranes strongly stain, granular cytoplasm, nuclei X 400
Negative control probed with anti-FIPV 1 and 2 Ab, counter-stained with F (ab’) 2 and Mayer’s azure counterstain.         X 1000.
TEM high magnification of Day 8 p.i. Cytoplasm granules with electron dense circular material. Scale bar = 200µm
 intermediately stained brown. 

 (Micrographs from Suderman et al. Three-Dimensional Human Bronchial-Tracheal Epithelial Tissue-Like Assemblies (TLAs) as Hosts Fro Severe Acute Respiratory Syndrome (SARS)-CoV Infection. 2006. NASA/TP-2006-213723.) 

  • The 3-D heterogenous models are bioengineered to the unique specifications of the investigator using normal

(non-transformed) parental cells demonstrate spontaneous recapitulation to the desired organoid tissue.

  • The 3-D cellular tissue models can be bioengineered on a variety of synthetic support matrices in 6-, 12- or 24- well sterile tissue culture plates.
  • This bioengineered format support rapid throughput analysis of therapeutic and/or prophylactic potential and cellular toxicity.
  • ll cells utilized for the 3-D models are early passage number acquired from recognized commercial source, characterized with a certificate of virus and bacteria pathogen-free.
  • Depending on individual cell replication characteristics, the initial 3-D cell culture organoids can be available for pathogenic agent exposure and analytics within three months and subsequent 3-D models on a bi-weekly basis for the duration of the investigation
  • Cell tissue – like aggregates can be documented by light, fluorescent and confocal microscopy and/or environmental scanning (E-SEM) and transmission electron (TEM) microscopy. Media can be sampled for progeny virus, cell-pathogen derived metabolites and cellular tissue for genomic and transcriptase analytics.

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