Anti-ADIPOQ Rabbit Polyclonal Antibody

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Description

Product Name : Anti-ADIPOQ Rabbit Polyclonal Antibody

Adiponectin Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike the CTRPs, which are expressed in a wide variety of tissues, adiponectin is reported to be expressed exclusively by differentiated adipocytes. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. It is present in high levels in normal human plasma, but is reduced in obese subjects and often in those with increased insulin resistance and type 2 diabetes, suggesting that adiponectin may be a useful pharmacological target in various metabolic diseases.
Antigen symbolADIPOQ
Antigen nameadiponectin, C1Q and collagen domain containing
Antigen synonymsADIPOQ
Antibody typePrimary
ClonalityPolyclonal
ConjugationUnconjugated
ReactivityHuman,Rat,Mouse
HostRabbit
Gene IDQ15848
IsotypeIgG
Western blotYes
ELISAYes
ImmunoChemistryYes
ImmunoFluorescenceYes
Epitopenear the C-Terminus
ImmunogenAdiponectin antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human adiponectin. The immunogen is located within the last 50 amino acids of Adiponectin.
FormLiquid
Molecular weightPredicted: 27 kDa Observed: 26 kDa
PurificationAdiponectin Antibody is affinity chromatography purified via peptide column.
Concentration1 mg/mL
Cross adsorptionNo
Storage bufferAdiponectin Antibody is supplied in PBS containing 0.02% sodium azide.
Storage temperatureAdiponectin antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Shipping temperature4 °C