Anti-COL1A2 Rabbit Polyclonal Antibody

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Description

Product Name :Anti-COL1A2 Rabbit Polyclonal Antibody

COL1A2 is the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity.This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
COL1A2 antibody can be used for detection of COL1A2 by ELISA at 1:62500. COL1A2 antibody can be used for detection of COL1A2 by western blot at 1 ?g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 – 100,000.
Antibody is purified by peptide affinity chromatography method.
Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Antigen symbolCOL1A2
Antigen namecollagen, type I, alpha 2
Antigen synonymsCOL1A2
Antibody typePrimary
ClonalityPolyclonal
ConjugationUnconjugated
ReactivityHuman,Dog
HostRabbit
Gene IDP08123
Western blotYes
ELISAYes
ImmunogenAntibody produced in rabbits immunized with a synthetic peptide corresponding a region of human COL1A2.
FormLiquid
Molecular weight150 kDa
PurificationAntibody is purified by peptide affinity chromatography method.
Storage bufferPurified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Storage temperatureFor short periods of storage (days) store at 4 °C. For longer periods of storage, store COL1A2 antibody at –20 °C. As with any antibody avoid repeat freeze-thaw cycles.
Shipping temperature4 °C