CellExp™ Human Recombinant PECAM1

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Size:10 ?g

SKU: hec-015 Category:

Description

Product Name : CellExp™ Human Recombinant PECAM1

>97% Pure active Human Recombinant human cell expressed PECAM-1
Determined by its ability to support the adhesion of activated Jurkat cells. The expected ED50 for this effect is 1.0 -1.5 ?g/ml.
PECAM is transmembrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. It is highly expressed at endothelial cell junctions, and also expressed in platelets and in most leukocyte sub-types. The primary function of PECAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. PECAM-1 has been implicated in the pathogenesis of various inflammation related disorders, including thrombosis, multiple sclerosis (MS), and rheumatoid arthritis. The human PECAM-1 gene codes for a 738 amino acid transmembrane glycoprotein containing a 118 amino acid cytoplasmic domain, a 19 amino acid transmembrane domain, and a 574 amino acid extracellular domain. Recombinant human PECAM-1 is a 572 amino acid glycoprotein comprising the extracellular domain of PECAM-1. Monomeric glycosylated PECAM-1 migrates at an apparent molecular weight of approximately 80.0-95.0 kDa by SDS-PAGE analysis under reducing conditions.
Protein/peptide namePECAM1PECAM1
Protein synonymsPlatelet endothelial cell adhesion molecule,CD31 antigenPlatelet endothelial cell adhesion molecule,CD31 antigen
Protein/peptide typeRecombinantRecombinant
SpeciesHumanHuman
SourceHEK293 cellsHEK293 cells
Endotoxin content< 0.1 ng/?g of protein (<1EU/?g).< 0.1 ng/?g of protein (<1EU/?g).
Purity>97%>97%
FormulationSterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium phosphate, pH 7.5Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium phosphate, pH 7.5
Molecular weight80-95 kDa80-95 kDa
Reconstitution instructionseconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortexReconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.