Product Name : Human Recombinant Anthrax Toxin Receptor 1
Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothelial cells. ANTXR1 plays a role in cell attachment and migration. ANTXR1 interacts with extracellular matrix proteins and the actin cytoskeleton, it mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. It is also involved in the angiogenic response of cultured umbilical vein endothelial cells, up-regulated in cultured angiogenic umbilical vein endothelial cells. Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI).
- Fusion-Tag: C-6 His tag
This recombinant protein can be used for biological assays. For research use only.
|Protein/peptide name||Anthrax Toxin Receptor 1|
|Protein synonyms||Anthrax Toxin Receptor 1,TEM8,Tumor Endothelial Marker 8,ANTXR1,ATR|
|Endotoxin content||<0.1 ng/ug (1 IEU/ug) as determined by LAL test.|
|Purity||> 95% as determined by reducing SDS-PAGE|
|Formulation||Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl,pH7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.|
|Molecular weight||33.56 kD|
|Storage conditions||Lyophilized protein should be stored at ?20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at ?20 °C for 3 months.|
|Tag sequence||C-6 His tag|