Product Name : Human Recombinant JAMB
Junctional Adhesion Molecule B (JAM-B) is a single-pass type I membrane protein that belongs to the juctional adhesion molecules family. JAM-B includes a signal sequence (aa 1-28), an extracellular region (aa 29-238) with one Ig-like C2-type domain and one Ig-like V-type domain, a transmembrane segment (aa 239-259), and a cytoplasmic domain (aa 260 – 298). JAMB is localized to the tight junctions between endothelial cells or epithelial cells. JAM-B is prominently expressed in the heart, placenta, lung, foreskin and lymph node. It is also present on the endothelia of other vessels. JAM-B acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.
- Fusion-Tag: C-Fc tag
This recombinant protein can be used for biological assays. For research use only
Protein/peptide nameJAMBProtein synonymsJunctional Adhesion Molecule B,C21orf43,Junctional Adhesion Molecule 2,Vascular Endothelial Junction-Associated Molecule,VE-JAM,JAM-B,JAM-2,VEJAM,CD322,JAM2Protein/peptide typeRecombinantSpeciesHumanSourceCellsSequencePhe29-Asn236Endotoxin content<0.1 ng/ug (1 IEU/ug) as determined by LAL test.Purity> 95% as determined by reducing SDS-PAGEFormulationLyophilized from a 0.2 um filtered solution of PBS, pH 7.4 . Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Molecular weight50.3 kDStorage conditionsLyophilized protein should be stored at ?20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at ?20 °C for 3 months.Tested applicationsused for biological assaysModificationC-Fc tagMolecular weight50.3 kD