Human Recombinant PECAM-1

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size:100 ?g

SKU: hec-018 Category:

Description

Product Name : Human Recombinant PECAM-1

PECAM is transmembrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. It is highly expressed at endothelial cell junctions, and is also expressed in platelets and most leukocyte sub-types. The primary function of PECAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. PECAM-1 has been implicated in the pathogenesis of various inflammation-related disorders, including thrombosis, multiple sclerosis (MS), and rheumatoid arthritis. The human PECAM-1 gene codes for a 738 amino acid transmembrane glycoprotein that contains a 118 amino acid cytoplasmic domain, a 19 amino acid transmembrane domain, and a 574 amino acid extracellular domain. Recombinant Human PECAM-1 is a 572 amino acid glycoprotein comprising the extracellular domain of PECAM-1. Monomeric glycosylated PECAM-1 migrates at an apparent molecular weight of approximately 80.0-95.0 kDa by SDS-PAGE analysis under reducing conditions. The calculated molecular weight of Recombinan Human PECAM-1 is 64.3 kDa.
Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.
Protein/peptide namePECAM-1
Protein synonymsPlatelet Endothelial Cell Adhesion Molecule,PECAM1,EndoCAM,CD31 antigen
Protein/peptide typeRecombinant
Protein FunctionCytokines and Growth Factors
SpeciesHuman
SourceHEK293 cells
ConjugationUnconjugated
Gene ID5175 P16284
SequenceENSFTINSVD MKSLPDWTVQ NGKNLTLQCF ADVSTTSHVK PQHQMLFYKD DVLFYNISSM KSTESYFIPE VRIYDSGTYK CTVIVNNKEK TTAEYQLLVE GVPSPRVTLD KKEAIQGGIV RVNCSVPEEK APIHFTIEKL ELNEKMVKLK REKNSRDQNF VILEFPVEEQ DRVLSFRCQA RIISGIHMQT SESTKSELVT VTESFSTPKF HISPTGMIME GAQLHIKCTI QVTHLAQEFP EIIIQKDKAI VAHNRHGNKA VYSVMAMVEH SGNYTCKVES SRISKVSSIV VNITELFSKP ELESSFTHLD QGERLNLSCS IPGAPPANFT IQKEDTIVSQ TQDFTKIASK SDSGTYICTA GIDKVVKKSN TVQIVVCEML SQPRISYDAQ FEVIKGQTIE VRCESISGTL PISYQLLKTS KVLENSTKNS NDPAVFKDNP TEDVEYQCVA DNCHSHAKML SEVLRVKVIA PVDEVQISIL SSKVVESGED IVLQCAVNEG SGPITYKFYR EKEGKPFYQM TSNATQAFWT KQKASKEQEG EYYCTAFNRA NHASSVPRSK ILTVRVILAP WK
Protease-freeY
Endotoxin levelLow
Endotoxin content>0.1 ng/?g
Biological activityBiological Activity tests can vary. Please refer to the Product CoA for information.
Purity0.97
FormLyophilized
FormulationFormulation can vary. Please refer to product CoA for information.
Molecular weight64.3 kDa
Reconstitution instructionsReconstitution instructions can vary. Please refer to the product CoA for info.
Storage conditionsStore at –20 °C prior to reconstitution.
Shipping temperatureAmbient
Molecular weight64.3 kDa