Human Recombinant PECAM1

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SKU: hec-040 Category:

Description

Product Name : Human Recombinant PECAM1

PECAM is transmembrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. It is highly expressed at endothelial cell junctions, and also expressed in platelets and in most leukocyte sub-types. The primary function of PECAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. PECAM-1 has been implicated in the pathogenesis of various inflammation related disorders, including thrombosis, multiple sclerosis (MS), and rheumatoid arthritis. The human PECAM-1 gene codes for a 738 amino acid transmembrane glycoprotein containing a 118 amino acid cytoplasmic domain, a 19 amino acid transmembrane domain, and a 574 amino acid extracellular domain. Recombinant human PECAM-1 is a 572 amino acid glycoprotein comprising the extracellular domain of PECAM-1. Monomeric glycosylated PECAM-1 migrates at an apparent molecular weight of approximately 80.0-95.0 kDa by SDS-PAGE analysis under reducing conditions
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.
Protein/peptide namePECAM1
Protein synonymsCD31,PECAM-1,endoCAM,Platelet endothelial cell adhesion molecule,PECA1,EndoCAM,CD31/EndoCAM,GPIIA’
Protein/peptide typeRecombinant
SpeciesHuman
SourceHEK293 cells
Biological activityEndotoxin level is less than 0.1 ng per ug (1EU/?g).
Purity>97%
FormulationLyophilized