Human Recombinant TL1A

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SKU: hec-088 Category:

Description

Product Name : Human Recombinant TL1A

TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NFkB activation, caspase activity, and apoptosis in responding cell lines. TL-1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6. Recombinant human TL-1A is a 22.0 kDa polypeptide of 194 amino acid residues.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.
Protein/peptide nameTL1A
Protein synonymsTL1,TNF ligand-related molecule 1,VEGI,Tumor necrosis factor ligand superfamily member 15,VEGI192A,TL1A
Protein/peptide typeRecombinant
SpeciesHuman
SourceE. coli
Biological activityBiological activity was determined by its ability to stimulate IFN – gamma production by human PBMC using a concentration range of 10.0 – 100.0 ng/mL. Note: Results may vary with PBMC donors.
Purity>98%
FormulationLyophilized