Product Name : Human Recombinant TL1A
TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NFkB activation, caspase activity, and apoptosis in responding cell lines. TL-1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6. Recombinant human TL-1A is a 22.0 kDa polypeptide of 194 amino acid residues.
Store in working aliquots at -20°C. Avoid freeze/thaw cycles.
|Protein synonyms||TL1,TNF ligand-related molecule 1,VEGI,Tumor necrosis factor ligand superfamily member 15,VEGI192A,TL1A|
|Biological activity||Biological activity was determined by its ability to stimulate IFN – gamma production by human PBMC using a concentration range of 10.0 – 100.0 ng/mL. Note: Results may vary with PBMC donors.|