Human Recombinant VEGF-121

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SKU: hec-020 Category:

Description

Product Name : Human Recombinant VEGF-121

Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with one being VEGF-121. The VEGF-121 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell function.

 

  • Animal-free

 

Shenandoah Biotechnology is a manufacturer of research grade recombinant proteins typically used as cytokines, growth factors and chemokines in cell based assays and cell culture. Each production lot is tested for QA and the expected values for each product can be viewed under the product specifications tab.
A COA is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions.  This product is for research use only and is not for use in humans.
Ordering information: Ships at room temperature; Store at ­20°C upon delivery.
Protein/peptide nameVEGF-121VEGF-121
Protein synonymsVEGF-A,glioma-derived endothelial cell mitogen,VPFVEGF-A,glioma-derived endothelial cell mitogen,VPF
Protein/peptide typeRecombinantRecombinant
Protein FunctionGrowth factorGrowth factor
SpeciesHumanHuman
SourceE. coliE. coli
SequenceMPMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENCDKPR RMPMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENCDKPR R
Protease-freeYYes
Animal-freeYY
Endotoxin levelLowLow
UniProtKBP15692-9P15692-9
Endotoxin content? 1.00 EUs/?g? 1.00 EUs/?g
Biological activityHUVEC proliferation at less than or equal to 5 ng/mL or (2.0 x 10^5 units/mg specific units)HUVEC proliferation at less than or equal to 5 ng/mL or (2.0 x 10^5 units/mg specific units)
Purity>95%?95%
FormulationLyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA)
Molecular weight14.1/28.3 (kDa) Dimer14.1/28.3 (kDa) Dimer
Reconstitution instructionsReconstitute with Sterile water at 0.1 mg/mLReconstitute with Sterile water at 0.1 mg/mL
Storage conditionsStore at –20 °C prior to openingStore at -20° C prior to opening
Shipping temperatureAmbientAmbient
Molecular weight14.1/28.3 (kDa) Dimer