Product Name : Human VEGF165
Vascular endothelial growth factor (VEGF) is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, Vascular endothelial growth factor (VEGF) plays a prominent role in normal and pathological angiogenesis.
Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant human Vascular Endothelial Growth Factor A165 (rhVEGF-A165) produced in Pichia pastoris is a disulfide-linked homodimer containing two polypeptide chains of 165 amino acids each. A fully biologically active molecule, rhVEGF-A165 has a molecular mass of 38.2kDa.
|Protein synonyms||Glioma-Derived Endothelial Cell Mitogen,Folliculostellate Cell-Derived Growth Factor,VPF|
|Sequence||APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR|
|Endotoxin level||<0.5 EU/?g|
|Formulation||Lyophilized after extensive dialysis against 25 mM HEPES and 150 mM NaCl|
|Molecular weight||38.2 kDa|
|Reconstitution instructions||Reconstituted in ddH2O at 100 ?g/mL|