Anti-AXL Rabbit Polyclonal Antibody

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SKU: hec-034 Category:

Description

Product Name : Anti-AXL Rabbit Polyclonal Antibody

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.
  • Recommended Dilutions: Western Blot: 1:100-1000; Flow Cytometry: 1:20-100; IHC-P: 1:100-500; IF(IHC-P): 1:50-200
Antigen symbolAXL
Antigen nameAXL Receptor Tyrosine Kinase
Antigen synonymsARK,JTK11,Tyro7,UFO
Antibody typePrimary
ClonalityPolyclonal
ConjugationUnconjugated
ReactivityHuman,Rat,Mouse
HostRabbit
Gene ID558
IsotypeIgG
Western blotYes
ImmunoChemistryYes
Flow cytometryYes
Immunogen180-230/894
Formliquid
PurificationPurified by Protein A
Concentration1 ?g/?l
Cross adsorptionNo
Storage bufferAqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
Storage temperatureStore at –20 °C for 12 months
Shipping temperature4°C