Product Name : Anti-ENG Rabbit Polyclonal Antibody
CD105 or Endoglin or GP160 is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists as an Oand N-glycosylated homodimer. Up-regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation-associated endothelial cell marker. CD105 binds to TGF-beta1 and Beta3 with high affinity but not TGF-beta2. Endoglin is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. It is a component of the transforming growth factor beta receptor complex as it binds TGFB1 and TGFB3 with high affinity. Endoglin has been shown to be a useful marker to identify tumor angiogenesis. Mutations in the endoglin gene produce hereditary hemorrhagic telangiectasia.
Endoglin antibody can be used in ELISA, and immunohistochemistry starting at 5 ?g/mL.
10 mM PBS, pH 7.6, 0.2% BSA, 15 mM sodium azide, before the addition of glycerol to 40%
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
|Immunogen||Endoglin antibody was raised against amino acids 26 – 176 of Endoglin (Human).|
|Storage buffer||10 mM PBS, pH 7.6, 0.2% BSA, 15 mM sodium azide, before the addition of glycerol to 40%|
|Storage temperature||Short term: 4 °C. Long term: Store at –20 °C. Avoid freeze-thaw cycles.|
|Shipping temperature||4 °C|
|Tested applications||Immunoaffinity Chromatography|