TNF-like 1 Recombinant Protein


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Product Name : TNF-like 1 Recombinant Protein

Tumor Necrosis Factor Ligand Superfamily Member 15 (TNFSF15) is a new member of the tumor necrosis factor family. TNFSF15 is predominantly an endothelial cell-specific gene, and recombinant TNFSF15 is a potent inhibitor of endothelial cell proliferation, angiogenesis and tumor growth. TNFSF15 exerts two activities on endothelial cells: early G1 arrest of G0/G1-cells responding to growth stimuli and programmed cell death of proliferating cells. These activities are highly specific to endothelial cells. TNFSF15 is also able to regulate the expression of several important genes involved in angiogenesis. These findings are consistent with the view that TNFSF15 functions as an autocrine cytokine to inhibit angiogenesis and stabilize the vasculature.
This recombinant protein can be used for biological assays. For research use only.
Protein/peptide nameTNF-like 1
Protein synonymsVascular Endothelial Cell Growth Inhibitor,TNFSF15,TNF Ligand-Related Molecule 1,TL1,VEGI,Tumor Necrosis Factor Ligand Superfamily Member 15
Protein/peptide typeRecombinant
SourceE. coli
Endotoxin content<0.1 ng/ug (1 IEU/ug) as determined by LAL test.
Biological activityED50 is less than 5 ?g/ml as determined by the dose-dependent inhibition of the proliferation of HUVEC cells.
Purity> 95% as determined by reducing SDS-PAGE
FormulationLyophilized from a 0.2 um filtered solution of 20mM PB, 250mM NaCl, pH 7.5. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Molecular weight21.86 kD
Storage conditionsLyophilized protein should be stored at ?20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at ?20 °C for 3 months.
Tested applicationsBioassay