Catalog #: 3DB33002
Storage: -80° C or 37°C
Format: 6, 12 or 24 well
Storing of BBB model thawing-sol and incubation medium.
BBB is stored at –80 ? and can be used within one month. Media is stored at below -20?.
blood brain barrier (BBB) specifically regulates molecular and cellular flux between the blood and the nervous tissue. We develop and characterize a highly reproducible Human in vitro model of the BBB using co-cultures of primary Human brain endothelial cells (HBEC), Human brain pericytes, and Human brain astrocytes to study receptors involved in transcytosis across the endothelial cell monolayer. Many drugs developed to treat Central Nervous System (CNS) disorders are unable to reach the brain parenchyma in therapeutically relevant concentrations. The BBB protects brain nervous tissue from the fluctuation of plasma composition, from pathogenic agents, and maintains homeostasis of the brain parenchyma by restricting non-specific flux of ions, peptides, proteins and even cells into and out the brain.